Analysis of major vitamin producers and production status

1/Vitamin E 3iL China Feed Industry Information Network - Based on feed, serving animal husbandry

Downstream industry: feed grade additives / animal feed (80%); medicine and food 3iL China feed industry information network - based on feed, service animal husbandry

Major manufacturers: DSM, BASF, Xinhecheng and Zhejiang Medicine. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Production: The global vitamin E market is relatively stable, maintaining a natural growth of 3-5% per year. Among them, DSM and BASF account for about 60% of production capacity, and Xinhecheng accounts for 40% of production capacity. All four companies are based on m-cresol and other raw materials. After more than 20 chemical reactions to prepare vitamin E, they have strong technical barriers. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

In addition, Xinhecheng has a strong technical advantage and has developed another new process based on acetone. Although the cost of the new process is comparable to the previous one, it can reduce the dependence on m-cresol and spread the risk. At present, the two processes are in production and the ratios are roughly equal. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

2/Vitamin C 3iL China Feed Industry Information Network - Based on feed, serving animal husbandry

Downstream industries: in the fields of medicine, health care products, feed and food additives, food and medicine and health care products accounted for 95.2% of vitamin C consumption, feeds accounted for 4.4%, and cosmetics accounted for 0.8%. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Major manufacturers: Northeast Pharmaceutical, North China Pharmaceutical, Shijiazhuang Group, Luwei Pharmaceutical, Jiangshan Pharmaceutical, Tianli Pharmaceutical, Tuoyang Industrial, etc. 3iL China Feed Industry Information Network - Based on feed, serving animal husbandry

Production: At present, the global demand for vitamin C is about 12-13 thousand tons, of which China exports 100,000 tons, accounting for more than 80% of global production capacity. In addition to China, the Dutch DSM company's factory in the UK is mainly used to meet the needs of high-end customers. It can be said that China is the world factory of vitamin C. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

The barriers to production of vitamin C are not high and the barriers to entry are low. Its production capacity is mainly “five major families”, namely, 25,000 tons of Northeast Pharmaceutical, 20,000 tons of North China Pharmaceutical, 35,000 tons of stone medicine, 30,000 tons of Luwei and 20,000 tons of Jiangshan. There are also many companies such as Tianli and Tuoyang, which have a production capacity of about 50,000 tons. China's annual vitamin C production capacity is about 200,000 tons, and there is a serious excess capacity. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

3/Vitamin B2 3iL China Feed Industry Information Network - Based on feed, serving animal husbandry

Downstream industry: feed and food additive industry, in which feed additives account for about 65% of total production, feed grade vitamin B2 is generally 80%; foods are mainly used as additives for foods such as flour, and a small amount (< 5 %) for medicine. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Major manufacturers: Guangji Pharmaceutical, BASF (BSF), DSM (DSM) 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Production: Vitamin B2 Global demand is about 7,000 tons, with an annual growth of about 3-5%. Because the feed is relatively high, there is a certain periodicity. The world's major producers are 4,800 tons of Guangji Pharmaceutical, 1,500 tons of BASF and 2,000 tons of DSM. The capacity of the three companies has exceeded 80% of the global total capacity and is already overcapacity. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

4/Vitamin B5 (D-calcium pantothenate) 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Downstream industry: mainly used for feed additives as well as medicines and foods, 60% of which are used for feed additives, 15% for veterinary drugs, 10% for medicines and 15% for food additives. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

The main manufacturers: Japan's first pharmaceutical fine chemicals company, Germany's BASF company, the Netherlands DSM company, Xinfu Pharmaceutical, etc. 3iL China feed industry information network - based on feed, service animal husbandry

Production situation: There are two main methods for preparing D-calcium pantothenate: (1) chemically synthesize DL-calcium pantothenate, and obtain D-calcium pantothenate by splitting DL-calcium pantothenate. (2) Resolution of the key intermediate DL-pantolactone by chemical or biological method to obtain D-pantolactone, and then D-pantolactone and β-aminopropionic acid to synthesize D- Calcium pantothenate, in which the cost of biologic resolution is 15% lower than the cost of chemical resolution. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Foreign D-calcium pantothenate production companies mainly include Japan's No. 1 Pharmaceutical Fine Chemicals Company, Germany's BASF Company, and Dutch DSM Company. Both BASF and DSM are produced by chemical methods, while Japan's No. 1 Pharmaceuticals uses the biological enzymatic resolution process to prepare the intermediate D-pantolactone, which is currently the most advanced process. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

In the country, only Xinfu Pharmaceutical had a bio-enzyme splitting process, but now Shandong Xinfa has also adopted this process. In terms of capacity distribution, domestic Xinfu Pharmaceutical has the largest production capacity of about 7,000 tons. After the earthquake in Japan in 2011, due to the destruction of infrastructure, Japan's first refinement suspended the production of calcium pantothenate. In this variety, the first refined profit situation is not ideal, the earthquake destroyed the infrastructure needed for production, the impact is more serious, and it is possible to withdraw from the calcium pantothenate market in the future. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

5/Vitamin B1 3iL China Feed Industry Information Network - Based on feed, serving animal husbandry

Downstream industry: mainly used for feed, a small part for food, medical care, and the field. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Major manufacturers: Hubei Huazhong Pharmaceutical Co., Ltd., Brother Technology, Jiangxi Tianxin Pharmaceutical Co., Ltd., etc. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Production: Vitamin B1 is a small variety of vitamins. In 2009, the total global demand for vitamin B1 was about 7,000 tons, of which the global demand for feed grade vitamin B1 was about 4,000 tons. Due to the industry's sluggish for many years, manufacturers have withdrawn from the vitamin B1 market. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

6/Vitamin K3 3iL China Feed Industry Information Network - Based on feed, serving animal husbandry

Downstream industry: mainly used as feed additives, accounting for more than 60%. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Major manufacturers: Brother Technology Co., Ltd., Yunnan Luliang Peace Technology Co., Ltd., Uruguay Dirox, Turkey Oxyvit. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

Production: The global demand for feed grade vitamin K3 is 5,500 tons. It is expected that the demand for small vitamins and vitamins K3 will increase by 4 to 6% per year in the next 5 years. Zhejiang Brother Technology is the industry leader. In 2010, it produced a market share of 37.9% with a production capacity of 2,000 tons. After the company went public, it increased the production capacity of vitamin K3 to 3,000 tons/year. 3iL China Feed Industry Information Network - based on feed, serving animal husbandry

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